Kyoto University
Graduate School of Biostudies
Molecular Neurobiology

業績Publications

2020年

  • Uchiyama K, Wakino S, Irie J, Miyamoto J, Matsui A, Tajima T, Ito T, Oshima Y, Yoshifuji A, Kimura I Itoh H. "Contribution of uremic dysbiosis to insulin resistance and sarcopenia." Nephrol Dial Transplant. gfaa076 (2020).
  • Igarashi M, Morimoto M, Suto A, Nakatani A, Hayakawa T, Hara K, Kimura I*. "Synthetic dietary inulin, Fuji FF, delays development of diet-induced obesity by improving gut microbiota profiles and increasing short-chain fatty acid production." PeerJ. 8, e8893 (2020).
  • Horiuchi H, Kamikado K, Aoki R, Suganuma N, Nishijima T, Nakatani A, Kimura I. "Bifidobacterium animalis subsp. lactis GCL2505 modulates host energy metabolism via the short-chain fatty acid receptor GPR43." Sci Rep. 10, 4158 (2020).
  • Kimura I*, Miyamoto J, Ohue-Kitano R, Watanabe K, Yamada T, Onuki M, Aoki R, Isobe Y, Kashihara D, Inoue D, Inaba A, Takamura Y, Taira S, Kumaki S, Watanabe M, Ito M, Nakagawa F, Irie J, Kakuta H, Shinohara M, Iwatsuki K, Tsujimoto G, Ohno H, Arita M, Itoh H, Hase K. "Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice." Science. 367, eaaw8429 (2020).
  • Mikami D, Kobayashi M, Uwada J, Yazawa T, Kamiyama K, Nishimori K, Nishikawa Y, Nishikawa S, Yokoi S, Kimura H, Kimura I, Taniguchi T, Iwano M. "Short-chain fatty acid mitigates adenine-induced chronic kidney disease via FFA2 and FFA3 pathways." Biochim Biophys Acta Mol Cell Biol Lipids. 1865, 158666 (2020)
  • Isobe J, Maeda S, Obata Y, Iizuka K, Nakamura Y, Fujimura Y, Kimizuka T, Hattori K, Kim YG, Morita T, Kimura I, Offermanns S, Adachi T, Nakao A, Kiyono H, Takahashi D, Hase K. "Commensal bacteria-derived butyrate promotes the T cell-independent IgA response in the colon." Int Immunol. 32, 243-258 (2020).
  • Kimura I*, Ichimura A, Ohue-Kitano R, Igarashi M. "Free Fatty Acid Receptors in Health and Disease." Physiol Rev. 100, 171-210 (2020).
  • 渡辺 啓太、向山 広美、宮本 潤基、木村 郁夫. "食由来栄養シグナルと腸内環境を介した宿主エネルギー代謝制御"糖尿病・内分泌代謝科 Vol.51 No.1, p1-7 (2020).
  • 向山 広美、宮本 潤基、木村 郁夫. "腸内細菌叢と肥満(脂質)" ヒトマイクロバイオーム最前線 第4編第5章 Vol.2 p393-399 (2020).
  • 水島 莉那、後田 ちひろ、木村 郁夫. "短鎖脂肪酸を介した宿主のエネルギー・糖代謝調節" 糖尿病学会誌 Vol.63, No.6 (2020).
  • 渡辺 啓太、向山 広美、宮本 潤基、木村 郁夫 "ケトン体生成を促す食事療法による体脂肪減少メカニズム" バイオサイエンスとインダストリー(B&I Vol.78, No.3, p196-201 (2020).

2019年

  • Shimizu H, Masujima Y, Ushiroda C, Mizushima R, Taira S, Ohue-Kitano R, Kimura I*. "Dietary short-chain fatty acids intake improves the hepatic metabolic condition via FFAR3." Sci Rep. 9, 16574 (2019).
  • Miyamoto J, Ohue-Kitano R, Mukouyama H, Nishida A, Watanabe K, Igarashi M, Irie J, Tsujimoto G, Satoh-Asahara N, Itoh H, Kimura I*. "Ketone body receptor GPR43 regulates lipid metabolism under ketogenic condition." Proc Natl Acad Sci U S A. 116, 23813-23821 (2019).
  • Shimizu H, Ohue-Kitano R, Kimura I*. "Regulation of host energy metabolism by gut microbiota-derived short-chain fatty acids." Glycative Stress Res. 6, 181-191 (2019).
  • Lee EY, Miedzbrodzka E, Zhang X, Hatano R, Miyamoto J, Kimura I. Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T. "Diet-Induced Obese Mice and Leptin-deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms." Int J Mol Sci. 20, E4448 (2019).
  • Miyamoto J, Igarashi M, Watanabe K, Karaki SI, Mukouyama H, Kishino S, Li X, Ichimura A, Irie J, Sugimoto Y, Mizutani T, Sugawara T, Ogawa J, Drucker DJ. Arita M, Itoh H, Kimura I*. "Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids." Nature Commun. 10, 4007 (2019).
  • Ohue-Kitano R, Taira S, Watanabe K, Masujima Y, Kuboshima T, Miyamoto J, Nishitani Y, Kawakami H, Kuwahara H, Kimura I*. "3-(4-Hydroxy-3-methoxyphenyl)propionic Acid Produced from 4-Hydroxy-3-methoxycinnamic Acid by Gut Microbiota Improves Host Metabolic Condition in Diet-Induced Obese Mice." Nutrients. 11, E1038 (2019).
  • Morita N, Umemoto E, Fujita S, Hayashi A, Kikuta J, Kimura I, Haneda T, Inoue A, Mimuro H, Maeda Y, Kayama H, Okumura R, Aoki J, Okada N, Kida T, Ishii M, Nabeshima R, Takeda K. "GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites." Nature. 566, 110-114 (2019).
  • Igarashi M, Watanabe K, Tsuduki T, Kimura I, Kubota N. "NAPE-PLD controls OEA synthesis and fat absorption by regulating lipoprotein synthesis in an in vitro model of intestinal epithelial cells." FASEB J. 33, 3167-3179 (2019).
  • 木村 郁夫 "代謝性疾患" 実験医学別冊 もっとよくわかる!腸内細菌叢 第2部6章-2 p69-72 (2019).
  • 宮本 潤基、木村 郁夫. "腸内細菌の働き解明" 腸内環境改善食物繊維の技術と市場 第3章 p19-26 (2019).
  • 五十嵐 美樹、須藤 明日香、木村 郁夫. "腸内細菌叢由来代謝物質とエネルギー代謝" 腸内環境改善食物繊維の技術と市場 第4章 p28-34 (2019).
  • 宮本 潤基、木村 郁夫. "短鎖脂肪酸による疾患制御" 医学のあゆみ 特集 Vol.269, No.13, 989-994 (2019).
  • 清水 秀憲、大植 隆司、木村 郁夫. "腸内細菌代謝産物と生体機能~循環器・代謝疾患の治療への応用" CARDIAC PRACTICE Vol.29, No.4, p23-27 (2019).
  • 木村 郁夫 "宿主代謝制御と腸内細菌叢" 実験医学(増刊号) Vol.37, No.2, p119-126 (2019).

2018年

  • Lee EY, Zhang X, Miyamoto J, Kimura I. Tanaka T, Furusawa K, Jomori T, Fujimoto K, Uematsu S, Miki T. "Gut carbohydrate inhibits GIP secretion via a microbiota/SCFA/FFAR3 pathway." J Endocrinol. 239, 267-276 (2018).
  • Watanabe K, Igarashi M, Li X, Nakatani A, Miyamoto J, Inaba Y, Sutou A, Saito T, Sato T, Tachibana N, Inoue H, Kimura I*. "Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids." PLoS One. 13, e0202083 (2018).
  • Nakatani A, Li X, Miyamoto J, Igarashi M, Watanabe H, Sutou A, Watanabe K, Motoyama T, Tachibana N, Kohno M, Inoue H, Kimura I*. "Dietary mung bean protein reduces high-fat diet-induced weight gain by modulating host bile acid metabolism in a gut microbiota-dependent manner." Biochem Biophys Res Commun. 501, 955-961 (2018).
  • Koshimizu TA, Honda K, Nagaoka-Uozumi S, Ichimura A, Kimura I, Nakaya M, Sakai N, Shibata K, Ushijima K, Fujimura A, Hirasawa A, Kurose H, Tsujimoto G, Tanoue A, Takano Y. "Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance." Nature Neurosci. 21, 820-833 (2018).
  • Miyamoto J, Watanabe K, Taira S, Kasubuchi M, Li X, Irie J, Itoh H, Kimura I*. "Barley β-glucan improves metabolic condition via short-chain fatty acids produced by gut microbial fermentation in high fat diet fed mice." PLoS One. 13, e0196579 (2018).
  • Kume H, Okazaki K, Yamamoto N, Omae Y, Ashida K, Takahashi T, Kimura I. "An Enteral Formula Containing Fermented Milk Products and Prebiotics Promotes Glucagon-Like Peptide-1 Secretion via Short Chain Fatty Acid Signaling." J Nutr Food Sci. 8, 1 (2018).
  • Ohue-Kitano R, Yasuoka Y, Goto T, Kitamura N, Park SB, Kishino S, Kimura I, Kasubuchi M, Takahashi H, Li Y, Yeh YS, Jheng HF, Iwase M, Tanaka M, Masuda S, Inoue T, Yamakage H, Kusakabe T, Tani F, Shimatsu A, Ogawa J, Satoh-Asahara N, Kawada T. "Alpha-linolenic acid-derived metabolites from lactic acid bacteria induce differentiation of anti-inflammatory M2 macrophage through G protein-coupled receptor 40." FASEB J. 32, 304-318 (2018).
  • Nakajima A, Kimura I*. "GPR41 / FFAR3." Encyclopedia of Signaling Molecules 2nd edition. 2194-2200 (2018).
  • 平 さつき、渡辺 啓太、大植 隆司、木村 郁夫. "食物繊維由来腸内細菌代謝物、短鎖脂肪酸と宿主代謝制御" ルミナコイド研究 Vol.22, No.2, p53-62 (2018).
  • 五十嵐 美樹、須藤 明日香、木村 郁夫. "腸内細菌叢由来代謝物質とエネルギー代謝" 代謝センシング―健康、食、美容、薬、そして脳の代謝を知る― 第Ⅲ編 第17章 p149-156 (2018).
  • 宮本 潤基、木村 郁夫. "2型糖尿病治療におけるプロバイオティクスの可能性" 腸内細菌叢を標的にした医薬品・保険機能食品の開発 第3章 第一節 p103-110 (2018).
  • 大植 隆司、平 さつき、木村 郁夫. "プロバイオティクス・プレバイオティクス臨床応用の現状 肥満、2型糖尿病" 臨床と研究 Vol.95, No.9, p51-56 (2018).
  • 五十嵐 美樹、須藤 明日香、木村 郁夫. "腸内細菌代謝物と抗肥満" フードスタイル21 Vol.22, No.8, p55-58 (2018).
  • 中谷 明穂、須藤 明日香、木村 郁夫. "腸内細菌およびその代謝産物による宿主エネルギー代謝制御機構" 腎臓内科・泌尿器科 Vol.7, No.6, p564-570 (2018).
  • 大植 隆司、平 さつき、木村 郁夫. "短鎖脂肪酸の産生と生理機能調節" 食品機能性脂質の基礎と応用 第1編 第2章 6節 p76-85 (2018).
  • 木村 郁夫、長谷 耕二. "腸内環境のリポクオリティと疾患制御" 実験医学(増刊号) Vol.36, No.10, p142-146 (2018).
  • 宮本 潤基、中谷 明穂、木村 郁夫. "脂肪酸代謝と腸内環境" アンチ・エイジング医学 Vol.14, No.1, p30-35 (2018).
  • 渡辺 啓太、平 さつき、木村 郁夫. "短鎖脂肪酸の産生・代謝と生理作用" 食と医療 Vol.4, p30-37 (2018).
  • 渡辺 啓太、宮本 潤基、木村 郁夫. "肥満と腸内細菌叢" Modern Physician.Vol.38, No.2, 158-161 (2018).
  • 木村 郁夫. "腸内細菌と肥満-宿主エネルギー代謝制御における腸内細菌の役割" 医学のあゆみ 特集号 Vol.264, No.1, 39-45 (2018).

2017年

  • Li X, Watanabe K, Kimura I*. "Gut Microbial Dysbiosis Drives and Implies Novel Therapeutic Strategies for Diabetes Mellitus and Related Metabolic Diseases." Front Immunol. 10, 3389 (2017).
  • Nakajima A, Kaga N, Nakanishi Y, Ohno H, Miyamoto J, Kimura I, Hori S, Sasaki T, Hiramatsu K, Okumura K, Miyake S, Habu S, Watanabe S. "Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice." J Immunol. 199, 3516-3524 (2017).
  • Li X, Shimizu Y, Kimura I*. "Gut Microbial Metabolites SHhort-chain Fatty Acids and Obesity." Biosci Microbiota Food Health. 36, 135-140 (2017).
  • Nakajima A, Nakatani A, Hasegawa S, Irie J, Ozawa K, Tsujimoto G, Suganami T, Itoh H, Kimura I*. "The short chain fatty acid receptor GPR43 regulates inflammatory signals in adipose tissue M2-type macrophages." PLoS One. 12, e0179696 (2017).
  • Kasubuchi M, Watanabe K, Hirano K, Inoue D, Li X, Terasawa K, Konishi M, Itoh N, Kimura I*. "Membrane progesterone receptor beta (mPRb/Paqr8) promotes progesterone-dependent neurite outgrowth in PC12 neuronal cells via non-G protein-coupled receptor (GPCR) signaling." Sci Rep. 7, 5168 (2017).
  • Miyamoto J, Kasubuchi M, Nakajima A, Kimura I*. "Anti-Inflammatory and Insulin-Sensitizing Effects of Free Fatty Acid Receptors." Handb Exp Pharmacol. 236, 221-231 (2017).
  • 宮本 潤基、中谷 明穂、木村 郁夫. "老化・代謝制御における腸内細菌叢" 実験医学(増刊号) Vol.35, No.20, p103-108 (2017).
  • 宮本 潤基、渡辺 啓太、木村 郁夫. "腸内細菌による脂肪酸代謝と宿主への影響" BIO Clinica, Vol.32, No.14, p19-23 (2017)
  • 宮本 潤基、木村 郁夫. "食事の健康に与える影響~腸内細菌の働き解明~" 月刊BIO INDUSTRY Vol.34, No.11, p9-13 (2017)
  • 細野 加奈子、中谷 明穂、木村 郁夫. "腸内細菌の肥満・糖尿病などのエネルギー代謝疾患への関与" Clinical Neuroscience  Vol.35, No.11, p1301-1303 (2017)
  • 木村 郁夫. "炭水化物(食物繊維)と腸内細菌" 食と医療 Vol.2, p13-23 (2017) 
  • 宮本 潤基、渡辺 啓太、木村 郁夫. "代謝制御における食物繊維・短鎖脂肪酸の関与" 内分泌・糖尿病・代謝内科 Vol.45, No.1, p7-13 (2017)
  • 粕渕 真由、木村 郁夫、國澤純. "腸内環境と腸管免疫・生体防御に関する新しいトピックス" 消化と吸収 Vol.39, No.2 p66-70 (2017)
  • 粕渕 真由、宮本 潤基、 木村 郁夫. "肥満と腸内細菌."Helicobacter Research Vol.21, No.3 p38-43, (2017).
  • 中島 啓、 木村 郁夫. "腸内細菌によるエネルギー代謝制御機構" 月刊糖尿病 Vol.9, No.5, 17-24 (2017).
  • 宮本 潤基、鈴木 卓弥、 木村 郁夫、田辺 創一. "腸内細菌脂質代謝物に見いだされた腸管バリア保護機能" 化学と生物 Vol.55, No.4, 278-284 (2017).
  • 中島 啓、 木村 郁夫. "腸内細菌叢を介した宿主エネルギー代謝と免疫制御機構‐糖尿病治療に向けて" 実験医学(増刊号) Vol.35, No.2, 145-151 (2017).

2016年

  • Miyamoto J, Kasubuchi M,Nakajima A, Irie J, Itoh H, Kimura I*. "The role of short-chain fatty acid on blood pressure regulation." Curr Opin Nephrol Hypertens. 25, 379-383 (2016).
  • Miyamoto J, Hasegawa S, Kasubuchi M, Ichimura A,Nakajima A, Kimura I*. "Nutritional Signaling via Free Fatty Acid Receptors." Int J Mol Sci. 17, 450 (2016).
  • Hasegawa S, Kasubuchi M, Terasawa K, Kimura I*. "Perspectives on membrane-associated progesterone receptors as prospective therapeutic targets." Curr Drug Targets. 17, 1189-1197 (2016).
  • Hoffmann HM, Trang C, Gong P, Kimura I, Pandolfi EC, Mellon PL. "Deletion of Vax1 from Gonadotropin-Releasing Hormone (GnRH) Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility." J Neurosci. 36, 3506-3518 (2016).
  • 木村 郁夫."腸内環境と宿主の肥満をつなぐ受容体."生命誌 年間号 つむぐ. Vol.84-87, p107-112 (2016).
  • 中島 啓、宮路 茜、木村 郁夫. "腸内細菌による宿主エネルギー代謝制御機構." 最新医学. Vol.71, No.9, p1787-1794 (2016).
  • 木村 郁夫. "食と腸内細菌代謝産物を介した宿主のエネルギー代謝制御."特別レポート食品と開発. Vol.51, No.11, p66-68 (2016).
  • 木村 郁夫. "食物繊維由来腸内細菌代謝産物、短鎖脂肪酸とエネルギー代謝." 腸内フローラシンポジウム. Vol.24, p31-35 (2016).
  • 木村 郁夫、宮路 茜、中島 啓. "腸内細菌代謝産物、短鎖脂肪酸と肥満." フードスタイル21. Vol.20, No.8, p44-47 (2016).
  • 粕渕 真由、宮本 潤基、中島 啓、木村 郁夫. "腸内細菌叢と食欲." 臨牀消化器内科. Vol.31, No.9, p1255-1260 (2016).
  • 木村 郁夫、粕渕 真由、宮本 潤基."腸内環境のフロンティア."Diabetes Frontier. Vol.27, No.3, p302-308 (2016).
  • 宮本 潤基、粕渕 真由、中島 啓、木村 郁夫. "腸内細菌とエネルギー代謝." 機能性食品と薬理栄養. Vol.10, No.1, p414-420 (2016).
  • 中島 啓、木村 郁夫."腸内細菌による宿主エネルギー代謝制御機構." Pharma Medica. Vol.34, No.5, p.21-26 (2016).
  • 宮本 潤基、粕渕 真由、長谷川 沙恵、木村 郁夫."腸内細菌と短鎖脂肪酸." The Lipid. Vol.27, No.2, p32-39 (2016).
  • 木村 郁夫、長谷川 沙恵、粕渕 真由、宮本 潤基. "食由来腸内細菌代謝産物、短鎖脂肪酸の代謝制御機能." 食品と開発. Vol.51, No.4, p8-10 (2016).
  • 木村 郁夫、粕渕 真由、長谷川 沙恵."腸内環境制御と肥満・糖尿病治療戦略." 実験医学. Vol.34, No.6, p880-885 (2016).
  • 宮本 潤基、長谷川 沙恵、木村 郁夫."腸内細菌叢と肥満(脂質)." ヒトマイクロバイオーム研究最前線. 第2章1節, p203-208 (2016).
  • 長谷川 沙恵、粕渕 真由木村 郁夫."腸内細菌の代謝に果たす役割." 診断と治療. Vol.104, No.2, p233-238 (2016).
  • 木村 郁夫、粕渕 真由."GPCR研究の最前線2016:食事性栄養センサー脂肪酸受容体." 医学のあゆみ 特集号. Vol.256, No.5, p541-546 (2016).

2015年

  • Ichimura A, Kimura I*. "Editorial: Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors." Front Endocrinol (Lausanne). 6, 178 (2015).
  • Ohta H, Kimura I, Konishi M, Itoh N. "Neudesin as a unique secreted protein with multi-functional roles in neural functions, tumorigenesis, and energy metabolism." Front Mol Biosci. 2, 24 (2015).
  • Ohta H, Konishi M, Kobayashi Y, Kishio A, Mochiyama T, Matsumura S, Inoue K, Fushiki T, Nakao K, Kimura I*, Itoh N. "Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity." Sci Rep. 5, 10049 (2015).
  • Kasubuchi M, Hasegawa S, Hiramatsu T, Ichimura A, Kimura I*. "Dietary Gut Microbial Metabolites, Short-chain Fatty Acids, and Host Metabolic Regulation." Nutrients. 7, 2839-2849 (2015).
  • Sekiguchi H, Kasubuchi M, Hasegawa S, Pelisch N, Kimura I, Ichimura A. "A Novel Antidiabetic Therapy: free Fatty Acids Receptors as Potential Druggable Targets." Curr Diabetes Rev. 11, 107-115 (2015).
  • Miyamoto J, Mizukure T, Park SB, Kishino S, Kimura I, Hirano K, Bergamo P, Rossi M, Suzuki T, Arita M, Ogawa J, Tanabe S. "A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40/MEK-ERK Pathway." J Biol Chem. 290, 2902-2918 (2015).
  • Temma T, Nishigori K, Onoe S, Sampei S, Kimura I, Ono M, Saji H. "Radiofluorinated Probe for PET Imaging of Fatty Acid Binding Protein 4 in Cancer." Nucl Med Biol. 42, 184-191 (2015).
  • 粕渕 真由、長谷川 沙恵、木村 郁夫."ヒト腸内細菌とエネルギー代謝." 肝胆膵. Vol.70, No.6, p821-826 (2015).
  • 木村 郁夫、長谷川 沙恵、粕渕 真由."食事由来腸内細菌代謝産物、短鎖脂肪酸と宿主代謝制御." 脂質栄養学. Vol.24, No.1, p33-40 (2015).
  • 木村 郁夫. "食と腸内細菌代謝産物を介した宿主エネルギー制御機構." 化学と生物. Vol.53, No.4, p202-204 (2015).
  • 木村 郁夫. "脂肪酸受容体によるエネルギー代謝制御." Annual Review 糖尿病・代謝・内分泌 2015. p170-176 (2015).
  • 木村 郁夫. "消化管細菌からみた糖尿病の病態と治療." 月刊糖尿病 1月号. Vol.7, No.1, p42-48 (2015).

2014年

  • Ichimura A, Hasegawa S, Kasubuchi M, Kimura I*. "Free fatty acids receptors as therapeutic target for treatment of diabetes." Front Pharmacol. 5, 236 (2014).
  • Kimura I*. "Host energy regulation via SCFAs receptors, as dietary nutrition sensors, by gut microbiota" Yakugaku zasshi. 134, 1037-1042 (2014).
  • Kimura I*, Inoue D, Hirano K, Tsujimoto G. "The SCFA Receptor GPR43 and Energy Metabolism." Front Endocrinol (Lausanne). 5, 85 (2014).
  • Hara T, Kashihara D, Ichimura A, Kimura I, Tsujimoto G, Hirasawa A. "Role of free fatty acid receptors in the regulation of energy metabolism." Biochim Biophys Acta. 1841, 1292-1300 (2014).
  • Inoue D, Tsujimoto G, Kimura I*. "Regulation of Energy Homeostasis by GPR41." Front Endocrinol (Lausanne). 5, 81 (2014).
  • Nishigori K, Temma T, Onoe S, Sampei S, Kimura I, Ono M, Saji H. "Development of a Radioiodinated Triazolopyrimidine Probe for Nuclear Medical Imaging of Fatty Acid Binding Protein 4." PLoS One. 9, e94668 (2014).
  • Nakayama Y, Wada A, Inoue R, Terasawa K, Kimura I, Nakamura N, Kurosaka A. "A Rapid and Efficient Method for Neuronal Induction of the P19 Embryonic Carcinoma Cell Line." J Neurosci Methods. 227, 100-106 (2014).
  • 木村 郁夫、粕渕 真由、長谷川 沙恵."代謝調節における脂肪酸受容体のもたらす新しい世界."消化と吸収. Vol.37, No.2, p62-66 (2014)
  • 木村 郁夫. "腸内細菌と肥満:腸内細菌代謝産物と宿主エネルギー制御." 医学のあゆみ 特集号. Vol.251, No.1, p107-111 (2014).
  • 木村 郁夫. "創薬応用を目指した脂肪酸受容体の機能解析「最前線」." ファルマシア. Vol.50, No.9, p867-871 (2014).
  • 木村 郁夫. "肥満と腸内細菌-宿主のエネルギー代謝調節と短鎖脂肪酸受容体-" 実験医学(増刊号) Vol.32, No.5, p768-772 (2014).

2013年

  • Larder R, Kimura I, Meadows JD, Clark D, Mayo S, Mellon PL. "Gene dosage of Otx2 is important for fertility in male mice." Mol Cell Endocrinol.377, 16-22 (2013).
  • Kimura I*, Nakayama Y, Zhao Y, Konishi M, Itoh N. "Neurotropic effects of neudesin in the central nervous system." Front Neurosci. 7, 111 (2013).
  • Hara T, Kimura I, Inoue D, Ichimura A, Hirasawa A. "Free fatty acid receptors and their role in regulation of energy metabolism." Rev Physiol Biochem Pharmacol. 164, 77-116 (2013).
  • Kimura I*, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T, Terasawa K, Kashihara D, Hirano K, Tani T, Takahashi T, Miyauchi S, Shioi G, Inoue H, Tsujimoto G. "The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43". Nature Commun. 4, 1829 (2013). 
  • Takeuchi M, Hirasawa A, Hara T, Kimura I, Hirano T, Suzuki T, Miyata N, Awaji T, Ishiguro M, Tsujimoto G. "FFA1-selective agonistic activity based on docking simulation using FFA1 and GPR120 homology models." Br J Pharmacol.168, 1570-1583 (2013).

2012年以前

  • Hara T, Hirasawa A, Ichimura A, Kimura I, Tsujimoto G. "Physiological functions of fatty acid receptors and their therapeutic potential." Nihon Yakurigaku Zasshi. 140, 275-279 (2012).
  • Kimura I*, Nakayama Y, Konishi M, Terasawa K, Ohta M, Itoh N, Fujimoto M. "Functions of MAPR (membrane-associated progesterone receptor) family members as heme/steroid-binding proteins." Curr Protein Pept Sci. 13, 687-696 (2012).
  • Inoue D, Kimura I, Wakabayashi M, Tsumoto H, Ozawa K, Hara T, Takei Y, Hirasawa A, Ishihama Y, Tsujimoto G. "Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation." FEBS Lett. 586, 1547-1554 (2012).
  • Ichimura A, Hirasawa A, Godefroy OP, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Komer A, Kiess W, Pigeyre M, Cajazzo R, Hul WV, Gaal LV, Horber F, Balkau B, Levy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, Froguel P. "Dysfunction of Lipid-sensor GPR120 leads to obesity in both mouse and human." Nature. 483, 350-354 (2012).  [Faculty of 1000 Biology selection]
  • Hara T, Hirasawa A, Ichimura A, Kimura I, Tsujimoto G. "Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic Disorders." J Pharm Sci. 100, 3594-3601 (2011).
  • Doi M, Ishida A, Miyake A, Sato M, Komatsu R, Yamazaki F, Kimura I, Tsuchiya S, Kori H, Seo K, Yamaguchi Y, Matsuo M, Fustin JM, Tanaka R, Santo Y, Yamada H, Takahashi Y, Araki M, Nakao K, Aizawa S, Kobayashi M, Obrietan K, Tsujimoto G, Okamura H. "Circadian regulation of intracellular G-protein signaling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus." Nature Commun. 2, 327 (2011). [Faculty of 1000 Biology selection]
  • Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, Miyauchi S, Kobayashi M, Hirasawa A, Tsujimoto G. "Short-chain fatty acids and ketones directly regulate sympathetic nervous system via GPR41." Proc Natl Acad Sci U S A. 108, 8030-8035 (2011).  [PNAS Direct Submission]
  • Sun Q, Hirasawa A, Hara T, Kimura I, Adachi T, Awaji T, Ishiguro M, Suzuki T, Miyata N, Tsujimoto G. "Structure-activity relationships of GPR120 agonists based on a docking simulation." Mol Pharmacol.78, 804-810 (2010). [Cover Art selection]
  • Kimura I*, Nakayama Y, Konishi M, Kobayashi T, Mori M, Ito M, Hirasawa A, Tsujimoto G, Ohta M, Itoh N, Fujimoto M. "Neuferricin, a novel extracellular heme-binding protein, promotes neurogenesis." J Neurochem. 112, 1156-1167 (2010).[Cover Art selection]
  • Kimura I*, Konishi M, Asaki T, Furukawa N, Ukai K, Mori M, Hirasawa A, Tsujimoto G, Ohta M, Itoh N, Fujimoto M. "Neudesin, an extracellular heme-binding protein, suppresses adipogenesis in 3T3-L1 cells via the MAPK cascade." Biochem Biophys Res Commun.381, 75-80 (2009).
  • Fujimoto M, Iida H, Homma T, Kimura I, Mori M, Hamana H. "Ca2+ inhibits the association of memantine with NMDA receptor-gated ion channels." Biol Pharm Bull.31, 1813-1815 (2008).
  • Kimura I*, Nakayama Y, Yamauchi H, Konishi M, Miyake A, Mori M, Ohta M, Itoh N, Fujimoto M. "Neurotrophic Activity of Neudesin, a Novel Extracellular Heme-binding Protein, is Dependent on the Binding of Heme to Its Cytochrome b5-like Heme/steroid-binding Domain." J Biol Chem.283, 4323-4331 (2008).
  • Wakahara T, Kusu N, Yamauchi H, Kimura I, Konishi M, Miyake A, Itoh N. "Fibin, a novel secreted lateral plate mesoderm signal, is essential for pectoral fin bud initiation in zebrafish." Dev Biol.303, 527-535 (2007).  
  • Kimura I, Konishi M, Miyake A, Fujimoto M, Itoh N. "Neudesin, a secreted factor, promotes neural cell proliferation and neuronal differentiation in mouse neural precursor cells." J Neurosci Res.83, 1415-1424 (2006).  [Faculty of 1000 Biology selection]
  • Kimura I, Yoshioka M, Konishi M, Miyake A, Itoh N. "Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity." J Neurosci Res.79, 287-294 (2005).
  • 市村 敦彦、原 貴史、木村 郁夫、平澤 明、辻本 豪三. "創薬標的としての遊離脂肪酸受容体:循環器疾患とメタボリックシンドローム." 血管. Vol.34, No.4, p145-152 (2011).
  • 木村 郁夫、辻本 豪三. "腸内細菌と脂肪酸受容体を介したエネルギー調節機構." 医学のあゆみ. Vol.239, No.2, p170-171 (2011).
  • 木村 郁夫、井上 大輔、前田 岳志、宮内 諭、市村 敦彦、平澤 明、辻本 豪三. "脂肪酸受容体:メタボリックシンドロームと循環器系疾患." 血管. Vol.33, No.3, p81-87 (2010).
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